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demonstrated that the intravitreal injection of synthetic melanin-like nanoparticles can clear free radicals, with reduced ROS production in RPE cells, finally alleviate the vascular leakage and show the anti-angiogenic activity in an AMD-like model

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doi: 10.3390/ijms22095010 [DOI] [PMC free article] [PubMed] [Google Scholar] 25.Rzepka Z, Buszman E, Beberok A, Wrzeniok D

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In mice with lipopolysaccharide (LPS)-induced C57BL/6, luteolin significantly inhibited the NF-B pathway through upregulation of A20 and Nrf2 in microglia and further demonstrated that A20 can exert its function as a downstream factor of Nrf2 [69]